Diurnal Variation in SARS-CoV-2 RT-PCR Test Results

False negative tests for SARS-CoV-2 are common and have important public health and medical implications. We tested the hypothesis of diurnal variation in viral shedding by assessing the proportion of positive versus negative SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) tests and cycle time (Ct) values among positive samples by the time of day. Among 86,342 clinical tests performed among symptomatic and asymptomatic patients in a regional health care network in the southeastern United States from March to August 2020, we found evidence for diurnal variation in the proportion of positive SARS-CoV-2 tests, with a peak around 1400 h and 1.7-fold variation over the day after adjustment for age, sex, race, testing location, month, and day of week and lower Ct values during the day for positive samples. These findings have important implications for public health testing and vaccination strategies.

https://pubmed.ncbi.nlm.nih.gov/34696614/

The Gut Bacteria, Hypertension and Sleep Apnea Connection

The connections between the most common form of sleep apnea, obstructive sleep apnea, and hypertension are already well established. In a recent study, researchers present evidence suggesting that gut bacteria balance may also be a factor linking those two common health conditions. Published in the Journal of Clinical Sleep Medicine, the study reviewed data from a number of studies and found that gut dysbiosis, an imbalance in the gut microbiome, was common to both hypertension and sleep apnea. Establishing a link between gut bacteria, hypertension and sleep apnea could lead to improved prevention and treatment plans for these conditions.

Understanding the links between gut bacteria, hypertension and sleep apnea and high blood pressure has the potential to yield better prevention and more targeted treatment. An important take-away that you can use today to promote better sleep and better health is the overall importance of diet.

Ultra-processed foods are destructive to the gut microbiome. Eating a healthy, well-balanced whole food diet promotes healthy, well-balanced gut bacteria. Combine that healthy diet with sufficient physical activity each day and you’ll sleep better at night while reducing your risk for numerous diseases and chronic health conditions, including hypertension and sleep apnea.

https://www.chronobiology.com/new-link-discovered-gut-bacteria-hypertension-and-sleep-apnea/

Updates: ICER & Chronoprakriti Pvt. Ltd.

Institute of Chronobiology Education & Research (ICER)

Since 2016 ICER is trying at all possible levels to get established on the fronts of academics, research and outreach activities. Following are some milestones I would like to enlist before announcing the new entity.

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Newsletter: Monthly publication since September 2018

Academic courses: Tried all possibilities, conducted till pre-covid era. Now not functional

Research: Submitted two proposals (AYUSH, BIRAC). Funding still awaited

Conferences: 2 National, 1 International 

Publication: Nil

Workshops: Conducted till pre-covid era. Now not functional

Textbook: Draft ready, Shikshan Prasarak Mandali (SPM) agreed to publish under their banner

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Chronoprakriti Pvt. Ltd.

Private company formation in 2021 to unburden ICER from professional and outreach activities.

Hope to initiate the consultancy by launching the interactive website soon. 

www.chronoprakriti.com

We will be launching an interactive website soon (most probably on, Dashahara 15th October 2021). We will provide all our paid services through this website. 

Chronoprakriti is a combination of Chronotype and Prakriti type which will provide personalized recommendations based on chronobiological as well as Ayurvedic understanding of body composition. 

I hope we will make this site a comprehensive resource about chronomedicine and chronotherapy

Chronobiology textbook

Introduction to Chronobiology is written for undergraduate students. It will be published by Late Prin. B .V .Bhide Foundation of Shikshan Prasarak Mandali, Pune. The book can be purchased by writing mail at chronobiology2017@gmail.com

Online survey to understand Impact of Online Education on Health

 An online survey by Shikshan Prasarak Mandali's Late Prin. B. V. Bhide Foundation: 

The COVID-19 pandemic forced universities around the world to shut down their campuses indefinitely and adopt online platforms for their educational activities. The colleges were not prepared for such a drastic change. Though there have been a lot of advances in information communication technology (ICT) in the last few decades and several online platforms to support online education were available, still it was a challenge for universities to complete their educational activities using an online platform in stipulated time period.

Additionally, professors and students faced a wide range of logistic, technical, financial, and social problems. The university suspended regular classes from 13th March 2020 and later a nationwide lockdown began in India on 25th March 2020. The academic programs of the university education are based on intense classroom and laboratory based activities. It was difficult to move all these academic activities online immediately. Moreover, it was assumed that the situation will normalize soon and the campuses could be reopened within weeks. But unfortunately the online teaching continued till date (July 2021). 

The use of electronic devices is increased during this period both for the purpose of educational activities along with recreation. As a result, students are continuously exposed to unintentional artificial light. The effects of acute and chronic exposure to artificial light at night (ALAN) via screen illumination on sleep, circadian rhythms, and related functional outcomes is known. Both acute and chronic illumination significantly disrupts sleep continuity and architecture and leads to daytime sleepiness, negative emotions, and attention difficulties. The exposure also alters circadian rhythms, subduing the normal nocturnal decline in body temperature and dampening nocturnal melatonin secretion. 

In summary, ALAN exposure from electronic screens has an immediate, detrimental, yet stable effect on sleep, circadian regulation, and next-day functional outcomes. The widespread use of electronic devices by students may cause adverse effects on health and performance.  We have developed a questionnaire in which we will be conducting survey of undergraduate and post graduate students about their opinion on different aspects of online education during the ongoing pandemic and its impact on their changed lifestyle and health.

For any query or feedback please write to us at: chronobiology2017@gmail.com

 https://forms.gle/fKWFJVTTTtB6Kfy1A

Chronobiology open forum

Open forum of this month was conducted on Saturday 26th June 2021 on Zoom platform. The topic for the forum was ' Online work - Effect on biological clock'. Total 9 participants attended the open forum. 

Depending upon the pandemic situation, we will decide to take online or offline open forum in next week. But we need a team to be involved in to the planning of the meeting so that it will be more effective with wider outreach.

Chronobiology textbook draft is taking good shape now. Hopefully we will come up with the e-book copy by next month. Mrs. Gauri Sathaye and all the members at Bhide foundation is actively involved into the textbook writing. We hope to get preface for the book from someone from the actively working in the field. 

A new commercial venture called 'ChronoPrakriti Private Limited' is registered for professional workshops and consultancy services. We are planning to talk on it in detail during next open forum.