Final year
project work for UG & PG life science students
@
Biological Rhythm Research Laboratory
(जैविक लयबद्धता संशोधन प्रयोगशाळा)
Affiliated to Cochlea Pune for Hearing and Speech
An NGO for deafness diagnosis & counseling
161A Modibaug, Ganeshkhind road, Pune 411016
What is Chronobiology?
Chronobiology is a
multidisciplinary branch of science dealing with study of biological rhythms. The free-running biological rhythms reflect the endogenous mechanisms
of cyclic temporization whose expression is morphologically seen as an internal
clock called body clock.
Biological rhythms
Three types of biological rhythms found in
human being namely ultradian, circadian and infradian.
Circadian
rhythms relates to any biological cyclic variations with a frequency of 1 cycle
in 24±4 hrs such as sleeping, feeding patterns in human being and other
animals.
Infradian
rhythms relates to certain biological rhythms with frequency lower than
circadian rhythms such as annual migration or reproductive cycles.
Ultradian
rhythms exhibit frequency higher than that of circadian rhythms. Examples of such rhythms include hormone release, heart rate,
thermoregulation, urination, bowel activity, appetite and nasal cycle.
Genetics of biological rhythms
Biological periodicities are driven by genetic
factors which causes a recursivity in a spectrum of frequencies ranging from
milliseconds to years. There are at least nine clock genes that play key role
in the mammalian body clock. The
temporal effect of genetic programming on genome is known as chronome. A branch of
chronobiology dealing with chronome analysis is called chronomics.
Chronobiometry
Chronobiology
can either be studied by use of model systems (e.g. Drosophila, Mouse, and Bat)
or by means of Autorhythmometry (AR). AR is nothing but self-measurement of the
biological rhythms by the subject himself. Adoption of AR, would permit the
assessment of the normal situation or condition of its health for each
individual. Chronobiological data can be analyzed either by inferential
chronobiometry or by non-inferential chronobiometry.
Chronobiological analysis may provide us to approach
risk, diagnosis and treatment dependent on dynamics of time, gender, age,
ethnicity and geographical location of the patient.
Chronoptherapy
Chronobiological approach of disease diagnosis and
management has a lot of untapped potential.
We need sufficient clinical data to validate this
hypothesis. Ultradian rhythms are not
studied so far in details even though many vital processes are known to be
ultradian in rhythmicity. We will measure and analyse nasal cycle pattern using
rhinomanometry and spirometry. Modern
science is aware about nasal cycle since over a century (Kayser 1895) but
without any physiological relevance associated to this unique phenomenon.
Project details
Online registration at: chronomics.blogspot.in
Batch I – 15th July 2016 – 30th
Nov 2016
Batch II – 15th Dec 2016 – 30th
Apr 2017
Online seminars – two lectures/week during semester
Project work – Four weeks during semester break
Facilities: 1) Instrumentation - a) Rhinomanometer
b) Spirometer
c) Thermistor based Breathing Sensor
2) Software
for statistical analysis of rhythmic data
3) Work
experience in clinical settings
Course content (2C / 30 lectures)
Chronobiology
(15), Autorhythmometry (5),
Rhinomanometry (5), Biological
rhythm as diagnostic tool (5)
Literature
Weekly PPTs, Research articles, Reference
book: Chronobiology – Biological timekeeping; Edited by Dunlap, Loros, &
DeCoursey Published by Sinauer.
Fees*
Rs. 3000/-
*Applicable to only those students who clears
theory exam and wish to participate in autorhythmometric data collection and
analysis.
Outcome
ü Understanding the dimension of time in
biological systems
ü Hands-on statistical analysis of biological
rhythmic data
ü Certificate of completion from BRRL
Terms and Conditions
Project work in Chronobiology is primarily for
final year under-graduate and post-graduate students. Those who have completed
the graduation or post graduation in life sciences are also eligible.
Project work is comprised of 2 credit theory
work of 30 lectures. Successful completion of theory work is prerequisite for
proceeding for 4 weeks of autorhythmometric work at Biological Rhythm Research
Laboratory.
The credits earned during this work cannot be
included in any university degree as the syllabus is not yet approved by any
university.
A registration fee for the project work is Rs.
3000-00 which includes course material, autorhythmometry and data analysis
software.
If a student failed to clear theory course then
Rs. 2500-00 will be refunded. (Rs. 500-00 will be deducted as processing
charges)
Registration by filling out the form at link: http://goo.gl/forms/rHi8gypfxGyzQ03C2
Registration is complete when fees are deposited
Bank
details
Janata Sahakari Bank, Karve road A/C No: 007220100040914
Janata Sahakari Bank, Karve road IFSC code: JSBP0000007
Janata Sahakari Bank, Karve road MICR code: 411074005
Registration for batch I – 8th July – 15th
July
Registration
for batch II – 8th Dec – 15th Dec
Project coordinator
Prashant S. Duraphe, PhD (University of Würzburg,
Germany)
Contact details: 8888810554/02025519099, duraphe@gmail.com
