Calorie restriction,
fasting, and circadian rhythms sync together for a long, healthy life in mice
Calorie restriction
(CR) involves chronic reduction of energy intake by 20 to 40% without inducing
malnutrition. CR extends life span in multiple animal models and reduces the
risk of age-associated disorders, most of which arise from metabolic
dysfunction and inflammation.
However, extended
daily fasting or aligning daily meal timing to the active period, even without
reducing energy intake, can also improve health and increase life span in model
organisms.
Acosta-RodrÃguez et al. reveal the specific contribution
of fasting and timing of calorie-reduced meals to the efficacy of CR, as
estimated by life-span extension in male mice.
https://www.science.org/doi/10.1126/science.adc8824
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